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(-)-Grandisin form Cryptocarya crassinervia
J M Saad1, E Soepadamo, X P Fang
1Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
Journal of Natural Products
|November 1, 1991
Abstract:
The known lignan (-)-grandisin [1] has been isolated from Cryptocarya crassinervia by using the brine shrimp lethality test to direct the isolation; its structure and relative stereochemistry have been determined by ir, 1H nmr, ms, and X-ray crystallography as an all-trans alpha, alpha'-diaryl-beta, beta'-dimethyltetrahydrofuran. Compound 1 is not significantly cytotoxic in our panel of human tumor cells.