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[Campylobacter pylori gastroduodenitis in children with juvenile rheumatoid arthritis]
Insights
Juvenile rheumatoid arthritis (JRA) in children is linked to gastroduodenal issues. While Campylobacter pylori (CP) is common, it may worsen existing lesions rather than cause them.
Area of Science:
- Pediatric Rheumatology
- Gastroenterology
- Immunology
Background:
- Juvenile rheumatoid arthritis (JRA) can affect multiple organ systems.
- Gastroduodenal involvement is observed in children with JRA, necessitating further investigation into its etiology and pathogenesis.
Purpose of the Study:
- To investigate the clinico-morphological characteristics of the gastroduodenal system in children with JRA.
- To assess the activity of gastroduodenitis and the local immune system.
- To determine the prevalence and role of Campylobacter pylori (CP) in gastroduodenal lesions in JRA.
Main Methods:
- Clinico-morphological and morphometric studies of the gastroduodenal system.
- Microbiological, histological, and electron microscopic examination for Campylobacter pylori.
- Correlation analysis between JRA manifestations, gastroduodenal status, and CP colonization.
Main Results:
- All 30 pediatric patients (4-15 years) with JRA exhibited gastric and duodenal mucosal lesions.
- Campylobacter pylori (CP) was detected in 86.7% of patients.
- A correlation was found between CP colonization and the activity of the rheumatoid process.
Conclusions:
- Gastroduodenal lesions are common in children with JRA.
- Campylobacter pylori (CP) is highly prevalent but may not be the primary cause of gastroduodenitis in JRA.
- CP may act as a pathogenetic factor in the development of erosive-ulcerous lesions in the gastroduodenal system of JRA patients.
Abstract:
Clinico-morphological study of the gastroduodenal system and also morphometric investigations of the degree of gastroduodenitis activity and the condition of the local immune system were made in 30 children aged from 4 to 15 years with juvenile rheumatoid arthritis (JRA). Microbiological, histological and electron microscopic methods for revealing Campylobacter pylori (CP) were used. Interrelationship between various clinical manifestations of JRA with the nature of gastroduodenal system affection and with the incidence of microbial colonization of SP was determined. All the patients with JRA had lesions in the gastric and duodenal mucosa, and some morphological features were revealed in them. SP was diagnosed in 86.7 per cent. There was a relation between the microbial clonization of SP and the degree of the rheumatoid process activity. It is suggested that SP does not play an etiological role in the development of gastroduodenitis in JRA but may serve as a pathogenetic factor in the development of an erosive-ulcerous lesion.