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Related Experiment Videos

Progressive systemic sclerosis with mental disorder.

H Shiraishi1, J Koizumi, T Suzuki

  • 1Department of Psychiatry, University of Tsukuba, Japan.

The Japanese Journal of Psychiatry and Neurology
|December 1, 1991
PubMed
Summary

This case study details a 43-year-old female with progressive systemic sclerosis who experienced psychotic episodes. Her symptoms were linked to organic hallucinosis and delusional disorder caused by the sclerosis.

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Area of Science:

  • Neurology
  • Psychiatry
  • Endocrinology

Background:

  • Progressive systemic sclerosis (PSS) is a complex autoimmune disease.
  • Comorbidities like Basedow's disease, atrial fibrillation, and diabetes mellitus can complicate patient management.
  • Psychotic exacerbations are rare but significant neurological manifestations of PSS.

Observation:

  • A 43-year-old female with PSS presented with recurrent psychotic episodes, including depressive, paranoid, and hallucinatory states.
  • Electroencephalograms (EEGs) showed persistent abnormalities.
  • 123I IMP SPECT revealed reduced cerebral blood flow during psychotic episodes.

Findings:

  • The patient's psychotic symptoms, including organic hallucinosis and delusional disorder, were attributed to PSS.

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  • Controlled Basedow's disease suggested the psychosis was primarily neurodegenerative.
  • Rare presentation of progressive diffuse sclerosis with paranoid hallucinatory state.

    • Implications:

    • Highlights the potential for severe neuropsychiatric manifestations in progressive systemic sclerosis.
    • Emphasizes the need for thorough neurological and psychiatric evaluation in PSS patients with altered mental status.
    • Suggests cerebral blood flow imaging may aid in diagnosing psychosis related to systemic sclerosis.