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Computer-controlled positive displacement pump for physiological flow simulation.

D W Holdsworth1, D W Rickey, M Drangova

  • 1Department of Medical Biophysics, University of Toronto, Ontario, Canada.

Medical & Biological Engineering & Computing
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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A novel computer-controlled pump precisely generates steady and pulsatile blood flow for hemodynamic studies and device calibration. Its design ensures high reproducibility, crucial for accurate vascular research and clinical applications.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology

Background:

  • Accurate simulation of blood flow is essential for studying vascular hemodynamics.
  • Calibration of clinical blood flow measurement devices requires precise flow generation.

Purpose of the Study:

  • To design and demonstrate a computer-controlled pump for vascular hemodynamics research.
  • To enable calibration of clinical blood flow measurement devices.

Main Methods:

  • A novel pump design utilizing two rack-mounted pistons driven by a micro-stepping motor.
  • Implementation of computer control for precise flow regulation.

Main Results:

  • The pump generates steady flow from 0.1 to 60 ml s-1.
  • Production of various pulsatile waveforms, including those with reverse flow, is achieved.

Related Experiment Videos

  • Demonstrated capability to replicate physiological flow patterns (e.g., common femoral and carotid arteries).
  • Excellent cycle-to-cycle reproducibility with an average variation of 0.1 ml s-1.

    • Conclusions:

    • The developed pump offers versatile and accurate blood flow simulation.
    • It is suitable for both fundamental hemodynamic research and practical device calibration.
    • The design ensures high precision and reproducibility for reliable experimental outcomes.