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Morphological and biochemical changes in peripheral nerves with aging.

H Drac1, M Babiuch, W Wiśniewska

  • 1Department of Neurology, School of Medicine, Warsaw.

Neuropatologia Polska
|January 1, 1991
PubMed
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Aging increases morphological changes in the ulnar nerve, with up to 35% of fibers affected in older adults. Despite age-related nerve fiber loss, the ulnar nerve retains its capacity for repair.

Area of Science:

  • Neuroscience
  • Gerontology
  • Pathology

Background:

  • The aging process can affect peripheral nerves, potentially leading to functional decline.
  • Understanding age-related changes in nerve morphology is crucial for diagnosing and managing neurological disorders.

Purpose of the Study:

  • To investigate the morphological and biochemical changes in the human ulnar nerve with advancing age.
  • To assess the nerve's capacity for repair across different age groups.

Main Methods:

  • Autopsy examination of ulnar nerves from 30 subjects (aged 24-98).
  • Morphological analysis including myelinated fiber density, diameter distribution, and teased fiber assessment.
  • Biochemical analysis of lipids in a subset of nerves.

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Main Results:

  • A significant increase in morphological nerve fiber changes with age, from 7-10% in adults to 35% in aged subjects.
  • Age-related loss of myelinated fibers was observed in older individuals.
  • Unspecific changes like axonal degeneration and segmental demyelination were noted across all ages.
  • The ulnar nerve demonstrated a consistent ability to repair fiber damage regardless of subject age.

Conclusions:

  • Aging is associated with increased unspecific morphological changes in the ulnar nerve.
  • While neuronal aging contributes to nerve changes, the ulnar nerve maintains a notable capacity for repair.
  • Biochemical changes are less pronounced than morphological alterations with aging.