Related Experiment Video
Updated: Aug 9, 2026
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Candidal oesophagitis in Cushing's syndrome
A Z Raju1, D Mathai, J P Singh
1Department of Medicine Unit-1, Christian Medical College Hospital, Vellore.
The Journal of the Association of Physicians of India
|September 1, 1991
Summary
Cushing's syndrome increases opportunistic infection risk, especially with ectopic ACTH. This case shows a rare presentation of Cushing's disease with esophageal candidiasis as a primary symptom.
Area of Science:
- Endocrinology
- Infectious Diseases
- Gastroenterology
Background:
- Cushing's syndrome is associated with increased susceptibility to opportunistic infections.
- Ectopic ACTH production is a known cause of Cushing's syndrome, often linked to specific infections.
- Cushing's disease, a distinct form of Cushing's syndrome, typically involves pituitary adenomas.
Observation:
- This report details a rare case of Cushing's disease.
- The patient presented with significant symptoms of candidal oesophagitis.
- Esophageal candidiasis was a major initial manifestation of the disease.
Findings:
- The case highlights an unusual presentation of Cushing's disease.
- It underscores the potential for severe opportunistic infections in endocrine disorders.
- Candidal oesophagitis can be a presenting sign in Cushing's disease.
Implications:
- Clinicians should consider endocrine disorders like Cushing's disease in patients with severe opportunistic infections.
- Early recognition of Cushing's syndrome manifestations is crucial for timely diagnosis and treatment.
- This case expands the understanding of the clinical spectrum of Cushing's disease and its associated infections.
Related Concept Videos
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:26Cushing Syndrome I: Introduction
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
01:27Esophageal Achalasia
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...