Toxicokinetics of aromatic amines in guppy, Poecilia reticulata

In this study the elimination kinetics of several chlorinated anilines and a tetrachlorobenzene in guppy, Poecilia reticulata, have been determined. The elimination of all the chlorinated anilines in fish showed a bi-phasic pattern, whereas the elimination characteristics of the tetrachlorobenzene are in agreement with a one-compartment model. Elimination of the chlorinated anilines is faster than elimination of the tetrachlorobenzene. The small differences in octanol-water partition coefficient of these compounds can only in part describe the differences in elimination rate. The observed differences might be attributed to differing biotransformation rates.