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Updated: Jul 8, 2026

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
Potentiometric membrane sensor for the selective determination of pethidine in pharmaceutical preparations and
Abdalla Shalaby1, Maha El-Tohamy, Magda El-Maamly
1Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Egypt. abdallashalaby@yahoo.com
Abstract:
The construction and general performance characteristics of a novel potentiometric PVC membrane sensor based on pethidine-phosphomolybdate as electroactive material for the determination of pethidine are described. This sensor exhibits fast, stable and near-Nernstain response 55.24 +/- 0.1, over the concentration range 1.10(-2)-1.10(-5)M for pethidine-phosphomolybdate over pH 2-7. No interferences are caused by many organic, inorganic cations, alkaloids and amino acids. The sensor proved useful for determining pethidine in pure forms, pharmaceutical injections and monitoring the content uniformity assay of ampoules. The designed sensor also show good accuracy for the determination of pethidine in biological fluids.
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