[Development of encephalitis in modeling of acute hemorrhagic stroke--a new variant of a somatic complication]

We studied immunological and morphological changes in rat brain in an acute period of experimental hemorrhagic stroke (HS). The latter was induced mechanically by the method of A. N. Makarenko et al (the area of destruction in the rat brain was 0.15-0.2 mm3 in the internal capsule (c.i.) of both hemispheres) in 105 noninbred white male and female mice (body mass 18-22 g) and 20 Wistar rats (body mass 200-220 g). The rats were decapitated on day 1, 3, 10. HS modeling in mice is accompanied with immune disorders: high production of hemagglutinating antibodies in parallel with low titer of hemolysines, significant reduction of thymic mass and intensification of delayed type hypersensitivity. Besides changes typical for an acute period of HS, histological studies of the brain revealed encephalitic lesions located both near HS foci and far from them in 10 test animals of 14 on days 3-10. We observed signs of productive ependymitis and focal vasculitis (capillaritis). The infiltrates consisted primarily of microglyal cells and lymphocytes. In the controls such changes occurred in 1 of 6 rats. The results show that in an acute period of HS in rats their brain may be affected with activated latent infection and encephalitis. The same phenomenon may be observed in humans.