[Metabolic syndrome and a course of osteoarthrosis]

To compare osteoarthritis (OA) course in patients with metabolic syndrome (MS) and those free of MS.

The presence and completeness of MS according to 2005 criteria were studied in 1350 OA patients (mean age 52.65 +/- 11.31 years). Most of the patients were women (74%) and persons over 45 years of age (80%).

MS was detected in 82.3% examinees with OA. MS was complete in 62.56%. MS-free OA was separately comorbid with arterial hypertension, obesity and diabetes mellitus. OA patients with MS had earlier clinical symptoms of OA, its longer duration, prevalence of generalized disease, more frequent development of knee joint synovitis and periarthritis, more intensive pain in the joints. OA patients with MS were more frequently affected with cardiovascular, gastrointestinal, renal and thyroid diseases, diabetes mellitus and complications of these diseases. This resulted in 2.5 times greater nosological load on the patients. 20% patients with OA were declared invalid, most of them (266, 90.17%) had MS.

Relationship of OA symptoms with metabolic factors may point to participation of the latter in the development and progression of OA.