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Updated: Jul 8, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Minor extended-spectrum beta-lactamases.

T Naas¹, L Poirel, P Nordmann

¹Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France. thierry.naas@bct.ap-hop-paris.fr

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|December 25, 2007

Summary

Extended-spectrum beta-lactamases (ESBLs) are enzymes causing antibiotic resistance. CTX-M types are now predominant, alongside TEM, SHV, and other ESBLs, impacting treatment options.

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The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

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Published on: February 1, 2018

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Last Updated: Jul 8, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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Published on: March 3, 2023

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Area of Science:

Microbiology
Molecular Biology
Biochemistry

Background:

Extended-spectrum beta-lactamases (ESBLs) are enzymes conferring resistance to beta-lactam antibiotics.
Plasmid-mediated ESBLs are a significant challenge in treating Gram-negative bacterial infections.

Purpose of the Study:

To review the evolution and prevalence of different ESBL types.
To highlight the increasing dominance of CTX-M-type ESBLs.

Main Methods:

Literature review of studies on ESBLs.
Analysis of epidemiological data on ESBL dissemination.

Main Results:

TEM and SHV types were initially dominant, arising from mutations in classic enzymes.
CTX-M-type ESBLs have become increasingly predominant over the last decade.
Other ESBL types (SFO, BES, BEL, TLA, GES, PER, VEB) and some OXA-type beta-lactamases with extended spectra are also described.

Conclusions:

The landscape of ESBLs is dynamic, with a shift towards CTX-M types.
Emergence and spread of diverse ESBLs necessitate ongoing surveillance and updated treatment strategies.