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Parenteral carbapenems.

P M Shah1

  • 1J. W. Goethe Universitaet, Arzt fuer Innere Medizin, Mikrobiologie und Infektion sepidemiologie, Biapenem Frankfurt, Germany. shah@em.uni-frankfurt.de

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|December 25, 2007
PubMed
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Carbapenems are potent antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including extended-spectrum beta-lactamase (ESBL)-producing pathogens. However, resistance can emerge during treatment, necessitating ongoing research and development.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Carbapenems represent a potent class of beta-lactam antibiotics.
  • They exhibit broad-spectrum antimicrobial activity against Gram-positive, Gram-negative, aerobic, and anaerobic pathogens.
  • Carbapenems are effective against extended-spectrum beta-lactamase (ESBL)-producing organisms.

Purpose of the Study:

  • To review the properties and applications of carbapenem antibiotics.
  • To highlight their role in treating serious infections, particularly those caused by ESBL-producing bacteria.
  • To acknowledge the emergence of resistance and ongoing development.

Main Methods:

  • Literature review of carbapenem properties and clinical use.
  • Analysis of in-vitro antimicrobial activity data.

Related Experiment Videos

  • Examination of licensed carbapenem agents and those under development.

    • Main Results:

    • Carbapenems demonstrate potent, rapidly bactericidal, time-dependent killing.
    • Their spectrum includes challenging pathogens like ESBL-producers.
    • Several carbapenems are licensed globally, with others in development.

    Conclusions:

    • Carbapenems are crucial for treating severe infections, especially those involving ESBL-producing bacteria.
    • The emergence of resistance necessitates continued surveillance and development of new agents.
    • Current carbapenem therapies include imipenem, meropenem, ertapenem, panipenem, and biapenem.