Serum binding proteins for growth hormone: origins, regulation of gene expression and possible roles

The above discussion highlights the heterogeneity of the family of GH receptors/GHBPs and their mRNAs. Considerable uncertainty still exists as to the interrelationships between the various forms, the specific mechanisms for their generation and their possible significance in terms of modulating GH action and receptor function. Collectively, the regulatory data indicate that while the mRNAs encoding the membrane and soluble GH receptors/GHBPs in the rat are expressed by the same broad distribution of tissues, they can be differentially regulated. Such regulated expression implies a functional basis for production of GHBP. The wide tissue distribution of GHBP mRNA also suggests a role for GHBP as a paracrine/autocrine effector molecule, perhaps in addition to an endocrine role. Additional studies, both in vitro and in vivo, perhaps utilizing highly purified recombinant GHBP, will be required to provide more definitive information as to the true physiological role(s) of the circulating GHBPs.