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Updated: Jul 8, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Consistent dissection of the protein interaction network by combining global and local metrics
Chunlin Wang1, Chris Ding, Qiaofeng Yang
1Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. wangcl@stanford.edu
Abstract:
We propose a new network decomposition method to systematically identify protein interaction modules in the protein interaction network. Our method incorporates both a global metric and a local metric for balance and consistency. We have compared the performance of our method with several earlier approaches on both simulated and real datasets using different criteria, and show that our method is more robust to network alterations and more effective at discovering functional protein modules.
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