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A Modified Technique for Transverse Aortic Constriction in Mice
Published on: August 18, 2022
Novel technique for aortic arch surgery under mild hypothermia.
Aristotelis Panos1, Patrick-Olivier Myers, Afkskendiyos Kalangos
1Clinic for Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland. a.panos@bluewin.ch
The Annals of Thoracic Surgery
|December 25, 2007
Summary
This study introduces a novel perfusion technique for open aortic arch repair using direct cannulation. This method enables safe surgical repair with reduced aortic cross-clamping and cardiopulmonary bypass times under mild hypothermia.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Vascular Surgery
Background:
- Aortic arch repair presents significant surgical challenges.
- Maintaining adequate cerebral and systemic perfusion during aortic arch surgery is critical.
- Current perfusion strategies require optimization for improved patient outcomes.
Purpose of the Study:
- To evaluate the initial experience and feasibility of a novel perfusion technique for open aortic arch repair.
- To assess the safety and efficacy of continuous antegrade perfusion of the brain and lower body.
- To determine the impact of this technique on aortic cross-clamping and cardiopulmonary bypass (CPB) times.
Main Methods:
- Open aortic arch repair was performed in 5 patients.
- Continuous antegrade perfusion was achieved via direct cannulation of the right axillary artery and descending aorta.
- Systemic perfusion was maintained under mild hypothermia (30°C) using a specific venous cannula.
Main Results:
- The technique allowed for safe open aortic arch repair.
- Shorter aortic cross-clamping and CPB times were observed.
- The method was associated with the benefits of mild hypothermia.
Conclusions:
- This novel perfusion strategy demonstrates potential for safe and effective open aortic arch repair.
- The technique may offer advantages in reducing procedural times and maintaining organ perfusion.
- Further evaluation is warranted to establish its general applicability in aortic arch surgeries.

