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Published on: August 13, 2019
Brachial artery responses in menopausal women using tibolone
Sebastián Carranza-Lira1, Juan R Cuan-Martínez, Sergio Rosales-Ortíz
1Hospital de Ginecobstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México DF. scarranzal@mexis.com
Objective:
To determine the effect of tibolone treatment on brachial artery pulsatility index (PI), resistance index (RI), and flux-mediated dilation (FMD) in postmenopausal Mexican women.
Method:
The FMD, PI, and RI of the right brachial artery were measured in 19 postmenopausal women before and after they received a hyperemic stimulus, first at baseline and then following a 6-month treatment with 2.5 mg of tibolone per day. Statistical analysis was performed using the t test.
Results:
The mean+/-SD age was 52.2+/-3.9 years; time since menopause was 24.6+/-16.7 months; and treatment duration was 5.7+/-2.0 months. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in PI were observed at baseline. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in both PI and RI were observed post-treatment.
Conclusion:
Tibolone treatment had a favorable effect on brachial artery responses to hyperemic stimuli.
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Ask the patient about their primary concern and thoroughly explore all reported symptoms.
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