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Updated: Jul 8, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Tumor necrosis factor antagonist mechanisms of action: a comprehensive review

Daniel Tracey1, Lars Klareskog, Eric H Sasso

  • 1Abbott Bioresearch Center, Worcester, MA, USA.

Pharmacology & Therapeutics
|December 25, 2007
PubMed

Insights

Tumor necrosis factor (TNF) plays a central role in immune-mediated inflammatory diseases like rheumatoid arthritis. TNF antagonists effectively treat these conditions, highlighting TNF

Area of Science:

  • Immunology
  • Molecular Biology
  • Rheumatology

Background:

  • Rheumatoid arthritis, Crohn's disease, psoriasis, psoriatic arthritis, and ankylosing spondylitis share common pathogenic mechanisms.
  • Tumor necrosis factor (TNF) is implicated in the pathogenesis of these immune-mediated inflammatory diseases.
  • Understanding TNF biology is crucial for developing targeted therapies.

Purpose of the Study:

  • To review the biology of TNF and its family members.
  • To discuss the mechanisms of action of TNF antagonists.
  • To explore potential mechanistic differences between available TNF antagonists.

Main Methods:

  • Review of scientific literature on TNF biology and immune-mediated inflammatory diseases.
  • Analysis of the mechanisms of action of TNF antagonists (adalimumab, etanercept, infliximab).
  • Comparison of efficacy and safety profiles of different TNF antagonists.

Main Results:

  • TNF antagonists have demonstrated remarkable efficacy in treating immune-mediated inflammatory diseases.
  • TNF is a central factor in the pathogenesis of these conditions.
  • Differences in mechanisms of action may influence the efficacy and safety of TNF antagonists.

Conclusions:

  • TNF antagonists are highly effective treatments for several immune-mediated inflammatory diseases.
  • TNF antagonists represent a cornerstone in managing these conditions.
  • Further research into mechanistic differences can optimize therapeutic strategies.

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