[The bioequivalence of doxycycline in two preparations in capsule form]

In a randomized cross-over study the bioavailability of doxycycline (CAS 17086-28-1) in two preparations was examined by determining AUC and Cmax. The bioavailability of Doxycyclin-Kapseln (T = test preparation) relatively to a reference preparation (R) in 20 healthy subjects. Statistical analysis of plasma concentration curve and maximum concentration showed no differences between the pharmaceutical preparations tested. Both preparations proved to be bioequivalent.