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Updated: Jul 8, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Immunomodulation in severe leptospirosis with multiple organ failure: plasma exchange, intravenous immunoglobulin or
E Meaudre1, Y Asencio, A Montcriol
1Département d'anesthésie-réanimation, hôpital d'instruction des Armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France. meaudre@club-internet.fr
Abstract:
We report a case of severe leptospirosis complicated with a multiple organ failure syndrome. A 62-year-old patient presented a picture associating fever, asthenia and myalgias, particularly intense on the calves. The assessment showed acute renal failure, hyperbilirubinemia, severe rhabdomyolysis and thrombocytopenia. Although initial management associating amoxicilline and continuous veino-venous hemodiafiltration, evolution was unfavourable, with SDRA and increase of hyperbilirubinemia. Administration of a bolus of 500 mg of methylprednisolone, associated with intravenous immunoglobulin (0,4 g/kg per day during five days), led to a rapid clinical and biological improvement. Immunomodulation aspects during leptospirosis are discussed.
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