Related Experiment Video
Updated: Jul 8, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?
Aymeric Binard1, Laëtitia Le Pottier, Alain Saraux
1Laboratory of Immunology, Brest University Medical School Hospital, Brest, France; Unit of Rheumatology, Brest,University Medical School Hospital, Brest, France.
Abstract:
Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.
Related Concept Videos
Inflammatory Bowel Disease III: Crohn's Disease
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease II: Ulcerative Colitis
Rheumatic Heart Disease I: Introduction
