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Increased risk of hip fracture among men with CKD

Annemarie C Dooley1, Noel S Weiss, Bryan Kestenbaum

  • 1Northwest Health Services Research and Development Program, Veterans Administration Puget Sound, University of Washington, Seattle, WA 98104-2499, USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 25, 2007
PubMed

Insights

Men with chronic kidney disease (CKD) not on dialysis have an increased risk of hip fracture. Advanced CKD stages significantly elevate fracture risk, approaching that of dialysis patients.

Area of Science:

  • Nephrology
  • Gerontology
  • Orthopedics

Background:

  • Chronic kidney disease (CKD) is linked to mineral metabolism disturbances and increased fracture risk, particularly in dialysis patients.
  • Fracture risk in non-dialysis CKD patients remains understudied.
  • Mineral metabolism disorders in CKD can impact bone health.

Purpose of the Study:

  • To investigate the association between chronic kidney disease (CKD) stages and hip fracture risk in men not requiring dialysis.
  • To quantify the relative risk of hip fracture across different stages of reduced glomerular filtration rate (GFR).

Main Methods:

  • Retrospective cohort study of 33,091 male veterans with estimated glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2).
  • Exclusion criteria included dialysis, organ transplant, cancer, and prior hip fracture.
  • Proportional hazards models analyzed the association between GFR stage and hip fracture risk.

Main Results:

  • A total of 176 hip fractures were identified.
  • Men with GFR 30-59 mL/min/1.73 m(2) had a 1.28-fold increased risk of hip fracture (95% CI, 0.88-1.66).
  • Men with GFR 15-29 mL/min/1.73 m(2) had a 3.98-fold increased risk of hip fracture (95% CI, 2.25-7.74).

Conclusions:

  • The study suggests that men with advanced CKD (stage 4, GFR 15-29 mL/min/1.73 m(2)) face a hip fracture risk comparable to that of dialysis patients.
  • Findings highlight the significant fracture risk associated with non-dialysis-dependent CKD.
  • Further research may be needed to explore sex-specific differences and interventions.
Abstract

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