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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Periodontal disease and other nontraditional risk factors for CKD

Monica A Fisher1, George W Taylor, Brent J Shelton

  • 1Case Western Reserve University, Cleveland, OH 44106-4905, USA. monica.fisher@case.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 25, 2007
PubMed

Insights

Periodontal disease and tooth loss are linked to a doubled risk of developing chronic kidney disease (CKD). This finding highlights the importance of oral health in managing CKD risk factors.

Area of Science:

  • Oral Health and Systemic Disease
  • Nephrology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a significant public health concern, often undiagnosed.
  • Periodontal disease is linked to systemic inflammation, suggesting a potential connection to CKD.

Purpose of the Study:

  • To investigate the association between periodontal disease and chronic kidney disease.
  • To identify potential risk factors for CKD.

Main Methods:

  • A cross-sectional study analyzed data from 12,947 adults in the Third National Health and Nutrition Examination Survey.
  • Periodontal status, including periodontal disease and edentulism, was assessed as the primary predictor.
  • Chronic kidney disease was defined by Kidney Disease Outcomes Quality Initiative stages 3 and 4 (GFR 15-59 mL/min/1.73 m²).
  • Logistic regression models adjusted for traditional and nontraditional risk factors.

Main Results:

  • The prevalence of CKD was 3.6%, periodontal disease was 6.0%, and edentulism was 10.5%.
  • Adults with periodontal disease had approximately double the odds of having CKD (aOR=1.60).
  • Edentulous adults also showed a nearly doubled likelihood of CKD (aOR=1.85), independent of other risk factors.

Conclusions:

  • Periodontal disease and edentulism are independently associated with chronic kidney disease.
  • These findings suggest that oral health status can aid in identifying individuals at risk for CKD.
  • Further research is needed to establish the temporal relationship.
Abstract

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