Related Experiment Videos
Synthesis and cardiovascular properties of fluorenyl derivatives related to verapamil
M N Romanelli1, E Teodori, S Scapecchi
1Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|October 1, 1991
Abstract:
A series of fluorenyl analogues of verapamil were synthesized and their cardiovascular properties on guinea pig isolated atria and isolated perfused heart evaluated. The compounds were also tested for their calcium antagonistic activity on guinea pig aorta. They were found to be poor calcium antagonists, but showed negative inotropic and antiarrhythmic properties. The results obtained seem to indicate that their mechanism of action differs from that of verapamil.