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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Bone Disorders01:29

Bone Disorders

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Tumor Progression02:07

Tumor Progression

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Metastasis

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Chronic Kidney Disease II: Clinical Manifestations

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Related Experiment Video

Updated: Jul 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma: primary bone tumor with systemic manifestations.

Mark H Bilsky1, Syed Azeem

  • 1Department of Neurosurgery, Box 71, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. bilskym@mskcc.org

Neurosurgery Clinics of North America
|December 25, 2007
PubMed
Summary

Multiple myeloma, a bone marrow cancer, can cause spinal fractures due to bone breakdown. Surgery for these spinal issues may fail if osteoporosis is also present.

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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

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Last Updated: Jul 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Area of Science:

  • Oncology
  • Orthopedics
  • Pathology

Background:

  • Multiple myeloma is a plasma cell cancer affecting bone marrow, frequently involving the spine.
  • Myeloma-induced bone disease involves increased osteoclast activity and decreased osteoblast function, leading to vertebral osteolysis and fractures.

Purpose of the Study:

  • To review the implications of multiple myeloma on spinal integrity and surgical outcomes.
  • To highlight the challenges posed by diffuse osteoporosis in surgical fixation for myeloma patients.

Main Methods:

  • Literature review of multiple myeloma, spinal involvement, and surgical treatment.
  • Analysis of the pathophysiology of myeloma-related bone destruction.
  • Evaluation of factors influencing surgical fixation success in osteoporotic bone.

Main Results:

  • Multiple myeloma commonly affects the spine, causing vertebral compression fractures.
  • These tumors are generally sensitive to chemotherapy and radiation.
  • Diffuse osteoporosis, common in myeloma patients, significantly increases the risk of fixation failure after spinal surgery.

Conclusions:

  • Spinal involvement in multiple myeloma necessitates careful consideration of treatment strategies.
  • Surgical intervention for spinal myeloma complications is rarely indicated.
  • Pre-existing osteoporosis is a critical factor predicting poor outcomes for spinal instrumentation in this patient population.