Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation for primary spine tumors.

Mark H Bilsky¹, Peter Gerszten, Ilya Laufer

¹Department of Neurosurgery, Box 71, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. bilskym@mskcc.org

Neurosurgery Clinics of North America

|December 25, 2007

Summary

Malignant primary spinal tumors are challenging due to complex surgery and resistance to standard treatments. Combining advanced radiation techniques with new systemic therapies offers hope for better tumor control and cures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Radiomics-Driven Model to Distinguish Between Clinically Similar Myxopapillary Ependymomas and Lumbosacral Schwannomas.

Neurosurgery practice·2026

Same author

Thoracic endoscopic spine surgery: systematic review of the literature and exploring the margin of benefit.

Journal of spine surgery (Hong Kong)·2026

Same author

Postoperative Epidural Disease and Local Control after Separation Surgery and Spine Stereotactic Body Radiation Therapy.

International journal of radiation oncology, biology, physics·2026

Same author

Cervical spinal cord stimulation disrupts proprioception yet improves voluntary arm reaching.

bioRxiv : the preprint server for biology·2026

Same author

Long-term outcomes of sacral and sacrococcygeal chordomas: a 30-year single-center experience comparing 3 treatment modalities.

The spine journal : official journal of the North American Spine Society·2026

Same author

Machine Learning-Based Prediction of Independent Ambulation Following Intramedullary Spinal Cord Tumor Resection.

Neurosurgery·2026

Area of Science:

Oncology
Neurosurgery
Radiation Oncology

Background:

Malignant primary spinal tumors pose significant management challenges.
Surgical en bloc resection is complex.
These tumors often exhibit chemoresistance and radioresistance.

Purpose of the Study:

To explore strategies for improving local tumor control and cure rates for malignant primary spinal tumors.
To address the treatment-resistant nature of these neoplasms.

Main Methods:

Review of current radiation techniques.
Evaluation of advances in systemic therapy.
Discussion of combined treatment approaches.

Main Results:

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Current treatments face limitations due to tumor complexity and resistance.

Advanced radiation techniques show promise for local control.

Systemic therapy advancements may enhance treatment efficacy.

Conclusions:

A multimodal approach combining novel radiation techniques and systemic therapies is crucial.
This integrated strategy may lead to improved outcomes for patients with treatment-resistant spinal tumors.