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Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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The Protein Data Bank: a historical perspective.

Helen M Berman1

  • 1Rutgers, The State University of New Jersey, USA. berman@rcsb.rutgers.edu

Acta Crystallographica. Section A, Foundations of Crystallography
|December 25, 2007
PubMed
Summary
This summary is machine-generated.

The Protein Data Bank (PDB) has evolved from a small archive to a major international resource for structural biology. Its growth reflects advancements in science, technology, and data sharing practices.

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Last Updated: Jul 8, 2026

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Area of Science:

  • Structural biology
  • Bioinformatics
  • Biochemistry

Background:

  • The Protein Data Bank (PDB) was established in 1971 as a grassroots initiative.
  • Initially, it housed a modest collection of a dozen molecular structures.

Observation:

  • The PDB has experienced significant expansion over the decades.
  • It currently serves as a critical international repository for structural biology data.

Findings:

  • The resource now contains over 40,000 entries.
  • Its growth is attributed to the dynamic interplay of scientific progress, technological innovation, and evolving attitudes towards data sharing.

Implications:

  • The PDB is an indispensable tool for researchers worldwide.
  • It facilitates advancements in understanding biological processes at the molecular level.
  • The resource's expansion highlights the importance of open data access in scientific discovery.