Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma

Mucin dissecting stroma suggests the presence of an invasive mucinous (colloid) carcinoma. However, in virtually every organ in which invasive mucinous carcinoma exists, there exist benign mimickers associated with dissecting mucin. This article reviews diagnostic criteria for the differential diagnosis of mucinous lesions of the breast, pancreas, biliary tract, colon, appendix, and bladder, emphasizing practical points, which we find helpful in daily diagnostic surgical pathology practice.