Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motor Unit Stimulation01:20

Motor Unit Stimulation

When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Smooth Muscle Contraction01:25

Smooth Muscle Contraction

Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
Muscle Contraction01:10

Muscle Contraction

In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive muscle...
Muscle Contraction01:15

Muscle Contraction

Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does excess exercise-induced cardiac activation at exercise onset independently generate increases in cardiovascular circuit flow?

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Leg blood flow and cardiac output are cyclically reduced during low-intensity exercise with intermittent KAATSU cuff inflation in young adults.

Physiological reports·2025
Same author

Mechanisms of exercise-induced reduction in peripheral arterial stiffness.

European journal of applied physiology·2025
Same author

Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial.

Translational exercise biomedicine·2025
Same author

A critical assessment of sympathetic restraint in submaximal exercise: Implications for integrated cardiovascular circuit control in exercise.

Experimental physiology·2025
Same author

Baseline arterial stiffness does not influence post-exercise reduction in pulse wave velocity.

Physiological reports·2025

Related Experiment Video

Updated: Jul 8, 2026

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

Rapid vascular responses to muscle contraction.

Philip S Clifford1, Michael E Tschakovsky

  • 1Department of Anesthesiology and Physiology, Medical College of Wisconsin and VA Medical Center, Milwaukee, WI, USA. pcliff@mcw.edu

Exercise and Sport Sciences Reviews
|December 25, 2007
PubMed
Summary

Muscle blood flow rapidly increases after exercise due to quick vasodilation. Mechanical stress on blood vessels during muscle contraction may trigger this response, enhancing blood supply.

More Related Videos

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
09:04

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Published on: February 20, 2018

In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy
07:31

In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy

Published on: May 28, 2007

Related Experiment Videos

Last Updated: Jul 8, 2026

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
09:04

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Published on: February 20, 2018

In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy
07:31

In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy

Published on: May 28, 2007

Area of Science:

  • Physiology
  • Vascular Biology
  • Exercise Science

Background:

  • Muscle contraction necessitates increased blood flow to meet metabolic demands.
  • The precise mechanisms and timing of exercise-induced vasodilation are still under investigation.

Purpose of the Study:

  • To investigate the rapid changes in muscle blood flow following contraction.
  • To identify the underlying mechanisms responsible for exercise-induced vasodilation.
  • To explore the role of mechanical factors in vascular responses during muscle activity.

Main Methods:

  • Continuous monitoring of muscle blood flow.
  • Direct observation of arteriolar diameter changes in contracting muscles.
  • Analysis of the relationship between mechanical deformation and vascular response.

Main Results:

  • Muscle blood flow demonstrated a significant increase within one second post-contraction.
  • Rapid vasodilation of arterioles within contracting muscles was directly observed.
  • Preliminary evidence indicated that mechanical deformation of the vascular wall is a potential causative factor.

Conclusions:

  • Rapid vasodilation is a key mechanism for immediate post-contraction hyperemia.
  • Mechanical forces exerted on blood vessels during muscle contraction may initiate rapid vasodilation.
  • Further research is warranted to fully elucidate the role of mechanical stimuli in regulating muscle blood flow during exercise.