[Diffused suberitrodermic psoriasis induced by infliximab]

The case of a young male is described, affected by Crohn disease with reactive Spondylarthritis essay with Infliximab to the dose of 3 mg/kgs. After 15 days from the third infusion, the patient developed a first psoriasis eruption to the palm of the hands and the plant of the feet, for which was begun topical therapy with cortisone. After an initial improvement, the patient suffered a diffusion of the psoriasis eruption to the whole trunk and the limbs with a suberitrodermic aspect. The possible pathogenesis of this paradoxical effect of the anti-TNF is considered. Also being still partly the causes, is important the inhibition of the TNF-alpha with consequent expansion of the INF-alpha, in turn potential inductor of psoriasis.