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Updated: Jul 8, 2026
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Hormone therapy in menopause: when not to use].
Poli Mara Spritzer1, Maria Celeste Osório Wender
1Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, RS. spritzer@ufrgs.br
Arquivos Brasileiros De Endocrinologia E Metabologia
|December 25, 2007
Summary
Menopause, marked by estrogen deficiency, causes various symptoms and health risks. This review highlights specific clinical situations where hormone therapy is contraindicated, despite its general effectiveness.
Area of Science:
- Reproductive Endocrinology
- Women's Health
- Clinical Pharmacology
Background:
- Menopause signifies the irreversible end of menstruation due to diminished ovarian function.
- Estrogen deficiency post-menopause is linked to vasomotor symptoms, urogenital atrophy, cognitive issues, and increased risks of osteoporosis and Alzheimer's disease.
- Estrogen therapy is highly effective for managing menopausal vasomotor and urogenital symptoms.
Purpose of the Study:
- To critically review and identify specific clinical conditions where hormone therapy is not recommended.
- To provide guidance on contraindications for hormone therapy in menopausal women.
Main Methods:
- Literature review and critical analysis of clinical guidelines and research.
- Focus on identifying contraindications for hormone therapy based on existing evidence.
Main Results:
- Estrogen therapy is effective for vasomotor and urogenital symptoms.
- Progesterone/progestins are necessary with estrogen for women with a uterus to prevent endometrial hyperplasia.
- Specific clinical scenarios exist where hormone therapy is contraindicated.
Conclusions:
- While hormone therapy is effective, its use must be carefully considered.
- Identifying and adhering to contraindications is crucial for patient safety.
- This review details the specific clinical conditions where hormone therapy should be avoided.
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