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Updated: Jul 8, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

[Small cell lung cancer].

Stefan Hoschek¹, Ursula Hoschek-Risslegger, Michael Fiegl

¹Landeskrankenhaus Hochzirl, Abteilung für Innere Medizin, Hochzirl, Osterreich.

Wiener Klinische Wochenschrift

|December 25, 2007

Summary

This summary is machine-generated.

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Small cell lung cancer (SCLC) treatment has seen progress, with combined chemoradiation as standard for localized stages. Advanced SCLC benefits from platinum-based chemotherapy, and prophylactic cranial irradiation is now recommended for extensive disease remission.

Area of Science:

Oncology
Pulmonology
Medical Research

Context:

Small cell lung cancer (SCLC) accounts for approximately 20% of all lung cancer cases.
Therapeutic advancements in SCLC have historically lagged behind those in non-small cell lung cancer (NSCLC).
Significant clinical progress has been made in SCLC treatment over the past two decades.

Purpose:

To review historical milestones and current trends in SCLC management.
To discuss optimal treatment strategies including radiotherapy, chemotherapy, and surgery.
To explore experimental therapies and management of special clinical situations in SCLC.

Summary:

Standard treatment for localized SCLC involves combined radiation and chemotherapy, with cisplatin and etoposide as the gold standard.

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Last Updated: Jul 8, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

Advanced SCLC stages are treated with platinum-based doublet chemotherapy, and prophylactic cranial irradiation is indicated upon remission in extensive disease.

Second-line treatments include topotecan and potentially pemetrexed, with bevacizumab showing promising results among targeted therapies.

Impact:

Highlights the importance of an interdisciplinary approach for optimal SCLC treatment planning.
Provides an up-to-date overview of SCLC therapeutic options, aiding clinicians in decision-making.
Discusses emerging strategies and special considerations, contributing to the evolving landscape of SCLC care.