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The autogenous tissue heart valve: current status.

C S Love1, J W Love

  • 1Autogenics, Newbury Park, Santa Barbara, California.

Journal of Cardiac Surgery
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

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Researchers developed a new method for creating autogenous tissue heart valves (ATHVs) from pericardium. This rapid, 5-minute technique results in durable, non-calcifying, and non-antigenic bioprosthetic valves.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Tissue Engineering

Background:

  • Xenograft bioprostheses face challenges with calcification and durability, potentially due to residual antigenicity.
  • Autogenous tissue heart valves (ATHVs) offer a promising alternative to overcome these limitations.

Purpose of the Study:

  • To refine a technique for rapid, intraoperative fabrication of a nonantigenic, noncalcifying, and durable pericardial ATHV.
  • To evaluate the performance and biocompatibility of the modified ATHV.

Main Methods:

  • Modified a previously described technique for rapid intraoperative fabrication of ATHVs.
  • Utilized autogenous pericardium immersed in glutaraldehyde for 5 minutes for valve construction.
  • Conducted in vitro testing using a pulse duplicator and accelerated life tester (over 800 million cycles).

Related Experiment Videos

  • Performed in vivo testing in a juvenile sheep model for 5 months.

    • Main Results:

    • The modified technique allows for the creation of a geometrically perfect trileaflet valve in 5 minutes.
    • In vitro testing demonstrated stent assembly durability exceeding 800 million cycles without failure.
    • In vivo explanted valves showed no tissue thickening or shrinkage, with pliable leaflets free from degenerative changes.

    Conclusions:

    • The modified technique for pericardial ATHV fabrication is reliable, easy to learn, and produces durable, pliable valves.
    • The glutaraldehyde-tanned autogenous pericardium appears to be nonantigenic and resistant to calcification and degeneration.
    • The pericardial ATHV shows significant potential as a long-lasting, biocompatible bioprosthetic valve replacement.