Related Experiment Video
Updated: Jul 8, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Renal pelvic hemorrhage and acute renal failure associated with carboplatin therapy
Srivilliputtur G Santhana Krishnan1, Brian VanderBrink, Gary Weiss
1Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
Abstract:
A 44-year-old woman with ovarian cancer and normal renal function developed gross hematuria after carboplatin therapy. Laboratory investigation revealed elevated blood urea nitrogen and serum creatinine values. Computed tomography scan of the abdomen and pelvis with or without contrast revealed bilateral hydronephrosis with high-attenuation material within the left renal pelvis and both ureters consistent with blood. Delayed images at 3 hours revealed intense nephrogram with delayed excretion of contrast bilaterally. She underwent cystoscopy and placement of ureteral stent bilaterally. She had brisk diuresis with associated progressive decrease in serum creatinine to baseline value.
Related Concept Videos
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Acute Pyelonephritis I: Introduction
Kidney Transplant II: Surgical Procedure
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Acute Kidney Injury II: Pathophysiology
