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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
The Mouse Genome Database (MGD): mouse biology and model systems.
Carol J Bult1, Janan T Eppig, James A Kadin
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. carol.bult@jax.org
Nucleic Acids Research
|December 26, 2007
Summary
The Mouse Genome Database (MGD) is a vital resource for genetic and phenotypic data in laboratory mice, aiding human disease research. Recent updates enhance data access and integration for translational studies.
Area of Science:
- Genomics
- Bioinformatics
- Translational Medicine
Background:
- The laboratory mouse is a key model organism for understanding human biology and disease.
- Integrating genetic, genomic, and phenotypic data is crucial for biological research.
Purpose of the Study:
- To describe the Mouse Genome Database (MGD) as a comprehensive resource for mouse genetic and phenotypic information.
- To highlight recent improvements in MGD data integration and accessibility.
Main Methods:
- Manual curation of biomedical literature.
- Integration of data from informatics resource centers (e.g., Ensembl, UniProt, NCBI).
- Collaboration on data and semantic standards (e.g., Gene Ontology, Mammalian Phenotype Ontology).
Main Results:
- MGD provides comprehensive gene characterization, standardized mouse phenotypes, and integrated sequence and genome variant data.
- Includes comparative genomic data for mammalian genes.
- New features include association of gene trap data and batch query capabilities.
Conclusions:
- MGD serves as a powerful data-mining platform for translational research.
- Enhanced data access facilitates comparative genotype, phenotype, and functional analyses.
- MGD is essential for leveraging mouse models in biomedical research.
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