[Synthesizing and biological quality of hydroxyapatite (HAP) ceramics]

Hydroxyapatite (HAP) ceramics were prepared by dry method from Ca3(PO4)2 and CaCO3. The compounds were single crystals of HAP. The biological tests, according to the test standard of biological quality, including cell culture cytotoxicity assay, pyrogenicity, hemolysis assay, systemic injection acute toxicity assay and implant usage assay in animal for the material have been performed. The results showed that the material has no any toxicity and stimulation for organism, has superior histocompatibility and ability to bind directly to bone. The particles of HAP have been used clinically for mandibular cyst and alveolus implants presently. The initial observation has shown that the wounds are all healed well and there is no any adverse reaction for the patients.