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Vascular disease in paediatric type 2 diabetes: the state of the art

T Brooks Vaughan1, Fernando Ovalle, Elaine Moreland

  • 1Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, The Kirklin Clinic, TKC 4th floor, 2000 6th Avenue South, Birmingham, AL 35233-0271, USA. brooks@uab.edu

Diabetes & Vascular Disease Research
|December 26, 2007
PubMed

Insights

Type 2 diabetes in children is rising, posing challenges for assessing and treating cardiovascular risks. Current guidelines lack consensus, with limited trial data available for this growing pediatric concern.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Risk Assessment
  • Type 2 Diabetes Mellitus

Background:

  • Type 2 diabetes is increasingly diagnosed in children and adolescents.
  • Cardiovascular risk factors are a significant concern in pediatric patients with type 2 diabetes.
  • There is a lack of consensus among experts on managing these risks.

Purpose of the Study:

  • To review current knowledge on assessing cardiovascular risk in pediatric type 2 diabetes.
  • To discuss the application of adult data to pediatric populations.
  • To explore potential treatment strategies and available pharmaceutical options.

Main Methods:

  • Review of existing literature on traditional and non-traditional cardiovascular risk indices.
  • Analysis of examination findings, biochemical markers, and non-invasive imaging.
  • Discussion of challenges in translating adult data to pediatric cases.

Main Results:

  • Limited high-quality trial data exists for pediatric type 2 diabetes.
  • Various methods for risk assessment (clinical, biochemical, imaging) have varying utility and limitations.
  • Few pharmaceutical treatments are formally approved for pediatric use.

Conclusions:

  • Managing cardiovascular risk in pediatric type 2 diabetes requires careful consideration of limited evidence.
  • Adaptation of adult guidelines must be approached cautiously.
  • Further research and approved pediatric treatments are urgently needed.

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