[Dynamic changes in fibrinolytic system in patients with acute myocardial infarction]

Dynamic change of serum tissue-type plasminogen, activator (t-PA) and PAI activity was studied in 22 cases with acute myocardial infarction (AMI) 11 cases with unstable angina (UA) and 24 healthy persons. The group of AMI was divided into two subgroups, one with severe complications, AMI-A subgroup and the other without complication, AMI-B subgroup. The results revealed: t-PA activity was decreased in AMI group, especially in AMI-A subgroup; PAI activity was markedly increased in AMI-A subgroup in first three days after onset; there was a marked decrease of active type in AMI-A subgroup. The study confirms that the function of fibrinolytic system is abnormal in patients with AMI and UA. The change of activity of t-PA and PAI is closely related with the severity of AMI. It is important to augment the activity of the fibrinolytic system in the treatment of AMI.