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Related Experiment Video

Updated: Jul 8, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Medical decision analysis in infectious diseases.

U D Allen1

  • 1Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
|December 27, 2007
PubMed
Summary

Medical decision analysis (MDA) offers a structured approach for infectious disease decisions. This framework can utilize costs and complications, not just utilities, aiding clinical practice.

Keywords:
Decision analysisInfectious diseases

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Last Updated: Jul 8, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Infectious Diseases
  • Medical Decision Analysis
  • Health Economics

Background:

  • Medical decision analysis (MDA) is crucial for complex infectious disease management.
  • Clinicians express discomfort with MDA, especially utility-based outcome measures.
  • Alternative outcome variables like costs and complications can be employed in MDA.

Purpose of the Study:

  • To enhance understanding of MDA's role in clinical infectious disease practice.
  • To review the fundamental principles of MDA.
  • To illustrate MDA application with a common clinical example.

Main Methods:

  • Review of MDA principles relevant to infectious diseases.
  • Discussion of alternative outcome measures beyond utilities.
  • Application of a clinical case example for illustration.

Main Results:

  • MDA provides an explicit, reproducible analytic framework for infectious diseases.
  • The framework supports cost-effectiveness analyses and risk-benefit assessments.
  • MDA can be adapted to various clinical scenarios in infectious disease.

Conclusions:

  • MDA is a valuable tool for infectious disease physicians facing complex decisions.
  • Understanding MDA principles and flexible outcome measures improves its clinical utility.
  • This paper aims to demystify MDA for infectious disease clinicians.