Related Experiment Video

Updated: Jul 8, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Safety of fluoroquinolones: An update

L Mandell1, G Tillotson

  • 1Division of Medicine, McMaster University, Henderson Site, Hamilton, Ontario.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
|December 27, 2007
PubMed

Insights

Fluoroquinolone antimicrobials show varied clinical use and side effects. Newer agents like moxifloxacin have fewer adverse events, but require careful evaluation as more data becomes available.

Area of Science:

  • Pharmacology
  • Infectious Diseases

Background:

  • The fluoroquinolone class of antimicrobials has been clinically available for over 13 years.
  • Extensive use of ciprofloxacin and levofloxacin contrasts with limited use or withdrawal of trovafloxacin and grepafloxacin.
  • Structural modifications enhance antibacterial activity but can lead to adverse events.

Purpose of the Study:

  • To examine newly introduced fluoroquinolones, moxifloxacin and gatifloxacin.
  • To assess anticipated class effects and review recent clinical experience with these agents.

Main Methods:

  • Review of structural modifications and their relation to adverse events.
  • Analysis of clinical data for moxifloxacin and gatifloxacin.

Main Results:

  • Newer fluoroquinolones are associated with common antimicrobial reactions like diarrhea, nausea, and headache at rates below 5%.
  • Specific structural substitutions are linked to particular adverse events.

Conclusions:

  • New fluoroquinolone agents require careful structural assessment.
  • Thorough clinical data collection is essential for evaluating the safety and efficacy of new fluoroquinolones.
Keywords:
Adverse eventsFluoroquinolonesSafetyTolerability

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