Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A measurement comparability study to support instrument harmonization in the Canadian longitudinal study on aging.

American journal of epidemiology·2026
Same author

Lessons learned from longitudinal biomonitoring and birth cohort studies: informing the future of reproductive health research in Canada.

Environmental health : a global access science source·2026
Same author

Older age and sex differences in the proportion of vital signs flagged as abnormal.

PloS one·2026
Same author

Correction: Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey.

PloS one·2026
Same author

Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey.

PloS one·2026
Same author

Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex.

Aging·2025

Related Experiment Video

Updated: Jan 3, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.5K

Multiple sclerosis and Epstein-Barr virus.

Ruth Ann Marrie1, Christina Wolfson

  • 1Montreal Neurological Institute, McGill University.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
|December 27, 2007
PubMed
Summary
This summary is machine-generated.

The link between Epstein-Barr virus (infectious mononucleosis) and multiple sclerosis (MS) remains unclear. While some studies suggest a connection, current epidemiological evidence is insufficient to confirm the virus as a cause of MS.

Keywords:
Epstein-Barr virusInfectious mononucleosisMultiple sclerosisReview

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.8K
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.6K

Related Experiment Videos

Last Updated: Jan 3, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.5K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.8K
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.6K

Area of Science:

  • Virology
  • Epidemiology
  • Neurology

Background:

  • Epstein-Barr virus (EBV) is a common human herpesvirus.
  • Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system.
  • A potential etiological link between EBV and MS has been hypothesized.

Purpose of the Study:

  • To systematically evaluate the existing epidemiological evidence regarding the role of Epstein-Barr virus in the etiology of multiple sclerosis.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE and the Cochrane Library.
  • Twenty-four relevant studies were identified and categorized by design (seroepidemiological, case-control, historical cohort).
  • Studies were assessed for methodological rigor based on established guidelines for MS epidemiology.

Main Results:

  • Significant heterogeneity was observed in the quality of the evidence across the reviewed studies.
  • Two robust cohort studies indicated an elevated risk of MS following infectious mononucleosis.
  • However, findings from other studies were not conclusive, showing considerable variability.

Conclusions:

  • The current epidemiological evidence is insufficient to definitively establish or refute the hypothesis that Epstein-Barr virus plays an etiological role in multiple sclerosis.
  • Further high-quality research is recommended, emphasizing large sample sizes, incident cases, and rigorous data collection methods.