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Updated: Jul 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[The antisynthetase syndrome: a cause of rapidly progressive interstitial lung disease]
Anne-Sophie Jordan Greco1, Jean-Claude Métrailler, Eric Dayer
1Département de médecine interne, CHCVs/Hôpital de Sierre. asjordan@freesurf.ch
Abstract:
The anti-synthetase syndrome is associated with inflammatory myopathy, interstitial lung disease, polyarthritis, Raynaud's phenomenon and typical skin lesions known as "mechanic's hands". Anti-Jo1 antibodies are frequently present. Interstitial lung disease is the most important feature, as it determines survival and the therapeutic attitude. We report here two cases of anti-synthetase syndrome with acute respiratory failure. Immunosuppressive treatment combining corticosteroids and cyclosporine lead to clinical improvement, regression of radiological lesions and improvement in pulmonary functions.
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