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Template switching: from replication fork repair to genome rearrangements

Dana Branzei1, Marco Foiani

  • 1FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy. dana.branzei@ifom-ieo-campus.it

Cell
|December 28, 2007
PubMed
Summary

Complex genome rearrangements in Pelizaeus-Merzbacher disease (PMD) may stem from replication errors. This study suggests template switching during DNA replication causes these nonrecurrent genomic rearrangements.

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