Differences in circulating insulin levels following glargine administration
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Updated: Jul 8, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Fidaa Ibrahim1, Georges Bagnard, Philippe Boudou
1Unit of Transfert in Molecular Oncology and Hormonology, Saint-Louis University Hospital, Assistance-Publique Hôpitaux de Paris, France.
Objectives:
To evaluate two-site non competitive insulin immunoassays [BI-INSULIN assay (IRMA) and an electro-chemiluminescent immunoassay (ECLIA)] in routine practice.
Design And Methods:
We studied 145 consecutive patients attending our Endocrine Department for general endocrine explorations and metabolic status investigations.
Results:
The ECLIA yielded higher results than IRMA in all but six patients treated by glargine.
Conclusions:
Insulin levels measured by Elecsys in patients treated by glargine are directly related to glargine biotransformation into detectable metabolite (M1).
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