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Updated: Jul 8, 2026
06:45
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Unexpected pulseless disease associated with recurrent venous thromboembolisms
Johann Morelle1, Michel Tintillier, Jean-Benoit Martinot
1Department of Internal Medicine and Nephrology, Clinique Sainte-Elisabeth, Namur. johannmorelle@hotmail.com
Summary
Klinefelter
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Hematology
Background:
- Klinefelter's syndrome is associated with venous thromboembolic disease.
- Arterial thrombosis is less common in Klinefelter's syndrome.
Observation:
- A patient with Klinefelter's syndrome presented with simultaneous venous thromboembolic disease and left subclavian artery thrombosis.
- This patient had elevated levels of plasminogen activator inhibitor type 1.
- No other common thrombophilic abnormalities were detected.
Findings:
- The case highlights a rare presentation of arterial thrombosis in Klinefelter's syndrome.
- Elevated plasminogen activator inhibitor type 1 may play a role in thrombotic events.
Implications:
- Further research is needed to understand the prothrombotic mechanisms in Klinefelter's syndrome.
- This case suggests a potential link between plasminogen activator inhibitor type 1 and both arterial and venous thrombosis in this population.
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