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Association of serum lipid indices with large artery atherosclerotic stroke

O Y Bang1, J L Saver, D S Liebeskind

  • 1Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

Neurology
|December 28, 2007
PubMed

Insights

Elevated triglycerides and non-high-density lipoprotein cholesterol (non-HDL) predict large artery atherosclerotic stroke risk, unlike low-density lipoprotein cholesterol (LDL). These findings suggest non-LDL lipid measures are valuable for assessing stroke risk.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Lipidology

Background:

  • Low-density lipoprotein cholesterol (LDL) is a primary target for vascular risk reduction in stroke patients.
  • Emerging data suggest other lipid indices may better predict vascular events.
  • This study investigates the association between serum lipid panel measures and large artery atherosclerotic (LAA) stroke.

Purpose of the Study:

  • To evaluate the relationship between various serum lipid indices and the occurrence of LAA stroke.
  • To determine if non-LDL lipid measures are better predictors of LAA stroke compared to LDL cholesterol.

Main Methods:

  • Prospective data from 1,049 ischemic stroke or TIA patients over 4 years were analyzed.
  • Fasting serum lipid indices were assessed for independent associations with LAA stroke.
  • Statistical adjustments were made for age, hypertension, diabetes, smoking, BMI, and statin use.

Main Results:

  • Of 1,049 patients, 23.5% had LAA stroke.
  • Elevated triglycerides and non-HDL cholesterol were significantly associated with LAA stroke (OR 2.69 and 2.39, respectively).
  • Low-density lipoprotein cholesterol (LDL) was not significantly associated with LAA stroke.

Conclusions:

  • Elevated serum triglycerides and non-HDL cholesterol, not LDL, are associated with LAA stroke.
  • These non-LDL lipid measures may offer utility in identifying patients at risk for atherosclerotic stroke.
  • The findings challenge the sole reliance on LDL for vascular risk assessment in stroke patients.
Abstract

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