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Related Concept Videos

Convergent Evolution01:54

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

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Related Experiment Video

Updated: Jul 8, 2026

Laboratory Maintenance of the Lower Dipteran Fly Bradysia (Sciara) coprophila: A New/Old Emerging Model Organism
04:26

Laboratory Maintenance of the Lower Dipteran Fly Bradysia (Sciara) coprophila: A New/Old Emerging Model Organism

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Molecular determinants of bat wing development.

K E Sears1

  • 1Howard Hughes Medical Institute, Pediatrics Department, University of Colorado at Denver, Denver, USA. kesears@alumni.uchicago.edu

Cells, Tissues, Organs
|December 28, 2007
PubMed
Summary

Bats evolved powered flight through forelimb specialization. Small changes in developmental gene expression drove significant bat wing morphology, including membrane formation and skeletal changes.

Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Comparative morphology

Background:

  • Bats are unique among mammals for their ability to achieve powered flight.
  • The evolution of the bat wing represents a significant morphological innovation.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying bat wing development.
  • To understand how genetic changes contribute to the evolution of flight in bats.

Main Methods:

  • Comparative genomic analysis
  • Gene expression studies
  • Developmental pathway investigation

Main Results:

  • Identified molecular changes in bat wing membrane formation.

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In situ Protocol for Butterfly Pupal Wings Using Riboprobes
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In situ Protocol for Butterfly Pupal Wings Using Riboprobes

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Last Updated: Jul 8, 2026

Laboratory Maintenance of the Lower Dipteran Fly Bradysia (Sciara) coprophila: A New/Old Emerging Model Organism
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  • Observed skeletal element elongation in bat wings.
  • Documented the reduction of the bat ulna during development.
  • Conclusions:

    • Small alterations in the expression of key developmental genes have resulted in substantial changes in bat wing morphology.
    • Bats provide a model for understanding how genetic changes drive major evolutionary innovations.