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Related Experiment Video

Updated: Jul 8, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive ¹⁹F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

Approximal fluoride concentration using different fluoridated products alone or in combination.

B Sarner¹, D Birkhed, P Lingstrom

¹Department of Cariology, Institute of Odontology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. barbro.sarner@odontologi.gu.se

Caries Research

|December 28, 2007

Summary

The order of using fluoride (F) products matters for maximizing approximal F concentration. Combining interdental brushes with F gel after brushing significantly boosts fluoride levels at approximal sites.

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Published on: December 10, 2013

Area of Science:

Dentistry
Cariology
Preventive Dentistry

Background:

Fluoride (F) is crucial for preventing dental caries.
Optimizing fluoride delivery to approximal tooth surfaces is essential for effective caries prevention.

Purpose of the Study:

To measure approximal fluoride concentration after using various fluoride-containing products.
To evaluate the impact of product combination and usage order on fluoride levels.

Main Methods:

Ten subjects participated in 17 randomized occasions across two trials.
Fluoride concentration was measured after using toothpicks, floss, interdental brushes with gels (0.2% or 0.32% F), toothpaste (0.32% F), and mouthrinse (0.2% NaF).

Main Results:

Mouthrinse yielded the highest approximal F, followed by toothpicks and brushing.
Combining brushing with flossing or toothpicks showed minimal order influence.
Using gels alone or with brushing increased approximal F compared to brushing alone.
Using interdental brushes with F gel after toothbrushing ('Inter Dental Brush Gel Method') significantly elevated approximal F.

Conclusions:

The sequence of applying fluoride products impacts approximal fluoride levels.
The 'Inter Dental Brush Gel Method' is effective for achieving high fluoride concentrations at approximal sites, enhancing caries prevention strategies.