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Published on: October 13, 2018
Idiopathic central precocious puberty in 28 boys
Bénédicte Pigneur1, Christine Trivin, Raja Brauner
1University Paris-Descartes, Assistance Publique-Hopitaux de Paris, Hopital Bicetre, Pediatric Endocrinology Unit, Paris, France.
Summary
Idiopathic central precocious puberty (CPP) in boys often has a familial component, with nearly half of cases showing a family history of early puberty. Puberty onset after age seven is typical for this condition.
Area of Science:
- Pediatric Endocrinology
- Reproductive Medicine
- Genetics
Background:
- Idiopathic central precocious puberty (CPP) is a rare condition in boys.
- Understanding familial factors is crucial for diagnosis and management.
Purpose of the Study:
- To analyze the clinical presentation of idiopathic CPP in boys.
- To determine the frequency of familial factors in boys with idiopathic CPP.
Main Methods:
- Retrospective analysis of data from 28 boys diagnosed with idiopathic CPP.
- Evaluation of hormonal profiles (LH, FSH, testosterone) and GnRH stimulation tests.
- Assessment for familial history of early puberty.
Main Results:
- Puberty onset occurred after age seven in all cases.
- Associated conditions included intrauterine growth retardation, Silver Russell syndrome, retinal degeneration, epilepsy, cryptorchidism, and inguinal hernia.
- A familial history of early puberty was identified in 40% of cases, with familial forms showing a higher body mass index.
Conclusions:
- Pubertal onset before age seven may indicate organic CPP.
- Nearly half of idiopathic CPP cases in boys have a familial basis.
- Familial history is an important consideration in the evaluation of CPP.
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