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Published on: August 4, 2019
[Association between p53 gene codon 72 polymorphism and keloid in Chinese population]
Li Yan1, Xiao-yan Lü, Chun-mei Wang
1Plastic Surgery Hospital, Chinese Academy of Medical Science, Beijing, China.
Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery
|December 29, 2007
Summary
Genetic variations in the p53 gene codon 72 were not linked to keloid formation in the Chinese population. However, the Arg/Arg genotype showed a higher prevalence in shoulder and back keloid patients.
Area of Science:
- Genetics
- Dermatology
- Molecular Biology
Background:
- Keloids are abnormal scars resulting from a complex interplay of genetic and environmental factors.
- The p53 gene, a tumor suppressor, plays a role in cell cycle regulation and apoptosis, making it a candidate for investigating scar formation.
- Polymorphisms in the p53 gene, specifically at codon 72, may influence protein function and susceptibility to certain conditions.
Purpose of the Study:
- To examine the association between the p53 gene codon 72 polymorphism and the genetic predisposition to keloid formation in the Chinese population.
- To determine if specific p53 genotypes correlate with keloid development in different body sites.
Main Methods:
- Genotyping of the p53 gene codon 72 was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis.
- The study included 60 keloid samples and 102 healthy control samples from China.
- Statistical analysis was conducted to compare genotype and allele frequencies between patient and control groups, and across different populations and body sites.
Main Results:
- No significant difference was observed in the distribution of p53 gene codon 72 polymorphism between keloid patients and healthy controls in the Chinese population.
- Allele frequencies for Pro and Arg variants of the p53 gene did not differ significantly between groups.
- A notable finding was the significantly higher frequency of the Arg/Arg genotype among patients with keloids located on the shoulder and back compared to other sites (P < 0.01).
Conclusions:
- The p53 gene codon 72 polymorphism is not significantly associated with keloid formation in the general Chinese population.
- The Arg/Arg genotype of the p53 gene may play a specific role in the development of keloids on the shoulder and back.
- Further research is warranted to explore the site-specific relationship between p53 gene codon 72 polymorphism and keloid formation.
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