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Updated: Jul 8, 2026
08:37
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
Innate and adaptive mechanisms to control [corrected] pathological intestinal inflammation
1Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1886, USA. kelsall@nih.gov
The Journal of Pathology
|December 29, 2007
Summary
The gut lining protects against bacteria, but failures can cause inflammatory bowel diseases. Dendritic cells are key to developing tolerance to gut microbes.
Area of Science:
- Gastroenterology and Immunology
- Gut Microbiome and Host Interactions
- Mucosal Immunity
Background:
- The intestine hosts a vast community of commensal microorganisms crucial for host metabolism.
- The gut mucosa possesses sophisticated protective mechanisms against microbial invasion and inflammation.
Purpose of the Study:
- To review innate and adaptive immune mechanisms of intestinal protection.
- To explore the role of immune system failure in inflammatory bowel disease (IBD) pathogenesis.
- To discuss the emerging role of dendritic cells in mucosal tolerance to commensals.
Main Methods:
- Review of existing literature on mucosal immunity, IBD, and dendritic cell function.
- Synthesis of findings on innate and adaptive immune responses in the gut.
- Analysis of the link between immune dysregulation and IBD development.
Main Results:
- Innate and adaptive immunity provide layered defense against bacterial translocation.
- Deficiencies in these protective mechanisms are implicated in inflammatory bowel diseases.
- Dendritic cells are identified as critical players in inducing tolerance to commensal bacteria.
Conclusions:
- Understanding mucosal defense mechanisms is vital for IBD research.
- Dendritic cells represent a promising target for therapeutic strategies aimed at restoring mucosal tolerance.
- Further research into immune regulation in the gut holds potential for IBD treatment.
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